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Gene Expression Data
Assay Details
Assay
Reference: J:121435 Samokhvalov IM, et al., Cell tracing shows the contribution of the yolk sac to adult haematopoiesis. Nature. 2007 Apr 26;446(7139):1056-61
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:5318362
Gene symbol: Runx1
Gene name: runt related transcription factor 1
Reporter: lacZ
Direct Detection
Results
Specimen E6.5: embryonic day 6.5; Runx1tm1Medv/Runx1+ (more )
Structure Level Pattern Image Note
TS9: ectoplacental cone Weak 1_E6.5 lacZ
TS9: extraembryonic visceral endoderm Weak 1_E6.5 lacZ
Specimen E7.5: embryonic day 7.5; Runx1tm1Medv/Runx1+ (more )
Structure Level Pattern Image Note
TS11: yolk sac Strong Regionally restricted 1_E7.5 lacZ There is strong expression in proximal visceral yolk sac region.
TS11: ectoplacental cone Weak 1_E7.5 lacZ
TS11: trophectoderm Weak Regionally restricted 1_E7.5 lacZ There is low level expression in trophectoderm associated with the ectoplacental cone.
TS11: allantois Absent 1_E7.5 lacZ
TS11: embryo Absent 1_E7.5 lacZ
Specimen E8.5: embryonic day 8.5; Runx1tm1Medv/Runx1+ (more )
Note: This embryo has 10-12 somite pairs.
Structure Level Pattern Image Note
TS13: blood Present 1_E8.5 lacZ--right Practically all staining is confined within blood circulatory cells.
TS13: vitelline artery Trace Regionally restricted 1_E8.5 lacZ--right Expression is present in a few endothelial cells of the omphalomesenteric artery.
Specimen E8.25-III: embryonic day 8.25-8.5; Runx1tm1Medv/Runx1+ (more )
Structure Level Pattern Image Note
TS12: blood vessel Present Single cells 1_E8.5 lacZ-III Expressing cells have been pushed from yolk sac blood vessels into the embryonic vasculature.
Specimen E8.5-IV: embryonic day 8.5; Runx1tm1Medv/Runx1+ (more )
Note: This embryo has 10-12 somite pairs.
Structure Level Pattern Image Note
TS13: blood Present 1_E8.5 lacZ--IV Practically all staining is confined within blood circulatory cells.
TS13: vitelline artery Trace Regionally restricted 1_E8.5 lacZ--IV Expression is present in a few endothelial cells of the omphalomesenteric artery.
Specimen E9.0: embryonic day 9.0; Runx1tm1Medv/Runx1+ (more )
Note: This embryo has 15-18 somite pairs.
Structure Level Pattern Image Note
TS14: umbilical artery Present Regionally restricted Expression is present in the endothelium of umbilical blood vessels.
Specimen E9.5: embryonic day 9.5; Runx1tm1Medv/Runx1+ (more )
Note: This embryo has 21-23 somite pairs.
Structure Level Pattern Image Note
TS15: hepatic primordium Present 1_E9.5 lacZ
TS15: aorta-gonad-mesonephros Present 1_E9.5 lacZ
TS15: umbilical artery Present 1_E9.5 lacZ Expression is present in umbilical vessels.
TS15: vitelline artery Present 1_E9.5 lacZ Expression is present in vitelline vessels.
TS15: olfactory placode Present 1_E9.5 lacZ Expression is present in some non-haematopoietic tissue, such as the olfactory epithelium.
TS15: spinal ganglion Present 1_E9.5 lacZ Expression is present in some non-haematopoietic tissue, such as spinal ganglia.
TS15: 1st branchial arch maxillary component Present 1_E9.5 lacZ Expression is present in some non-haematopoietic tissue, such as the maxillary processes.
TS15: genitourinary system Present Regionally restricted 1_E9.5 lacZ Expression is present in some non-haematopoietic tissue, such as the external genitalia primordium.
Specimen S2-E7.5-8.25: embryonic day 7.5-8.25; Runx1tm1Medv/Runx1+ (more )
Note: These embryos are all pre-somitic stage, ranging in age from early bud neural plate to the late headfold. These embryos were over-stained.
Structure Level Pattern Image Note
TS11: allantois Absent S2
TS11: embryo Absent S2
TS11: yolk sac Present S2
Specimen S3-E8.5-9.0: embryonic day 8.5-9.0; Runx1tm1Medv/Runx1+ (more )
Note: This embryo has 12-14 somite pairs.
Structure Level Pattern Image Note
TS13: yolk sac Strong Spotted S3_a , S3_d Expression is localized mostly in small clusters of cells in the proximal region of the yolk sac. The majority of primitive blood cells are faintly expressing; there is a high level of expression in the cell clusters closely associated with vasculature.
Specimen S3-E9.0: embryonic day 9.0; Runx1tm1Medv/Runx1+ (more )
Note: This embryo has 18-20 somite pairs.
Structure Level Pattern Image Note
TS14: yolk sac Present Spotted S3_e , S3_b The clusters of expression are starting to disintegrate; they are closely associated with yolk sac vasculature.
Specimen S3-E9.5: embryonic day 9.5; Runx1tm1Medv/Runx1+ (more )
Note: This embryo has 23-25 somite pairs.
Structure Level Pattern Image Note
TS15: yolk sac Strong Single cells S3_c , S3_f The expressing clusters seen earlier are almost completely dissociated into single cells and have spread along the yolk sac vasculature. There is no expression in primitive blood.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory