Summary | Mutation origin | Mutation description | Recombinase activity | Phenotypes | Find Mice (IMSR) | References

Symbol:	Crim1tm1(GFP/cre/ERT2)Pzg
Name:	cysteine rich transmembrane BMP regulator 1; targeted mutation 1, Pumin Zhang
MGI ID:	MGI:5317218
Synonyms:	Crim1-GCE
Gene:	Crim1  Location: Chr17:78507677-78684021 bp, + strand  Genetic Position: Chr17, 48.09 cM
Alliance:	Crim1tm1(GFP/cre/ERT2)Pzg page

Germline Transmission:	Earliest citation of germline transmission: J:159099
Parent Cell Line:	AB2.2 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1b-m2

Allele Type:    Targeted (Inducible, Recombinase, Reporter) Inducer:    tamoxifen Mutation:    Insertion   Crim1tm1(GFP/cre/ERT2)Pzg expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Crim1 (MGI:1354756)   Mutation details: A targeting vector containing GFP-Cre/ERT2 cassette (GCE) and FRT site flanked Kanamycin/neomycin selection cassette was used to disrupt the exon containing the ATG translation start-site. The construct was electroporated into 129S7/SvEvBrd-Hprt1b-m2 derived AB2.2 embryonic stem (ES) cells. Correctly targeted ES cells were injected into recipientblastocysts. The resulting chimeric animals were crossed to C57BL/6 mice. (J:159099)

Activity:	Tissue activity of this recombinase allele
Driver:	Crim1 (mouse) Summary of all recombinase alleles driven by Crim1. Alliance mouse Crim1 gene page

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Crim1 Mutation:	51 strains or lines available

Original:	J:159099 McMahon A, et al., Summary of mouse strains characterized by GUDMAP consortium. Unpublished. 2010;
All:	4 reference(s)