Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Lrp2tm2(EGFP/cre)Tew
Name:	low density lipoprotein receptor-related protein 2; targeted mutation 2, Thomas E Willnow
MGI ID:	MGI:5314898
Synonyms:	Lrp2tmEGFP
Gene:	Lrp2  Location: Chr2:69254679-69416373 bp, - strand  Genetic Position: Chr2, 40.74 cM
Alliance:	Lrp2tm2(EGFP/cre)Tew page

Germline Transmission:	Earliest citation of germline transmission: J:181474
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Recombinase) Mutations:    Insertion, Intragenic deletion   Lrp2tm2(EGFP/cre)Tew expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Lrp2 (MGI:95794)   Mutation details: A minigene construct contained intron 1 of the rabbit beta-globin sequence followed by an EGFP/cre fusion gene with a nuclear localization signal and a translational stop codon. Homologous recombination in ES cells replaced exon 1 and 3.6 kb of intron 1 of the Lrp2 locus with the EGFP/cre minigene. (J:181474)

Activity:	Tissue activity of this recombinase allele
Driver:	Lrp2 (mouse) Summary of all recombinase alleles driven by Lrp2. Alliance mouse Lrp2 gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lrp2 Mutation:	260 strains or lines available

Original:	J:181474 Christ A, et al., LRP2 Is an Auxiliary SHH Receptor Required to Condition the Forebrain Ventral Midline for Inductive Signals. Dev Cell. 2012 Feb 14;22(2):268-78
All:	1 reference(s)