About   Help   FAQ
Mirc14 Complex/Cluster/Region Detail
Summary
  • Symbol
    Mirc14
  • Name
    microRNA cluster 14, including Mir181a-1 through Mir181b-1
  • Feature Type
    complex/cluster/region
  • IDs
    MGI:5313566
  • Cluster Members
    Mir181a-1, Mir181b-1 (2 members)
Location &
Maps
more
  • Sequence Map
    Chr1:137894193-137894456 bp
    From MGI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, Syntenic
Strain
Comparison
more
  • SNPs within 2kb
    51 from dbSNP Build 142
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    24 phenotypes from 5 alleles in 5 genetic backgrounds
    10 phenotypes from multigenic genotypes
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased DN3 thymocyte, double-positive T cell, early thymic T cell progenitors, germinal B cells and peripheral B cell numbers, increased latency to Notch-induced leukemia and increased marginal zone B cell number.
Other Database
Links
less
miRBase MI0000697, MI0000723
References
more
  • Summaries
    All 19
    Phenotypes 18
  • Earliest
    J:105741 Griffiths-Jones S, et al., miRBase: microRNA sequences, targets and gene nomenclature. Nucleic Acids Res. 2006 Jan 1;34(Database issue):D140-4
  • Latest
    J:340964 Jimenez MT, et al., The miR-181 family regulates colonic inflammation through its activity in the intestinal epithelium. J Exp Med. 2022 Dec 5;219(12)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory