Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Synbtm1.1Ics
Name:	syncytin b; targeted mutation 1.1, Mouse Clinical Institute
MGI ID:	MGI:5308858
Gene:	Synb  Location: Chr14:69526793-69531748 bp, - strand  Genetic Position: Chr14, 36.04 cM
Alliance:	Synbtm1.1Ics page

Germline Transmission:	Earliest citation of germline transmission: J:180242
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A loxP site was inserted upstream of the coding sequence. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of the coding region. Flp-mediated recombination removed the neo cassette and left the coding sequence floxed. (J:180242)

Targeted disruption of the single exon Synb gene to generate the Synbtm1.1Ics and Synbtm1.2Ics alleles

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Synb Mutation:	7 strains or lines available

Original:	J:180242 Dupressoir A, et al., A pair of co-opted retroviral envelope syncytin genes is required for formation of the two-layered murine placental syncytiotrophoblast. Proc Natl Acad Sci U S A. 2011 Nov 15;108(46):E1164-73
All:	1 reference(s)