Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Dnase1l2tm1Eckh
Name:	deoxyribonuclease 1-like 2; targeted mutation 1, Leopold Eckhart
MGI ID:	MGI:5308556
Gene:	Dnase1l2  Location: Chr17:24659061-24662075 bp, - strand  Genetic Position: Chr17, 12.39 cM, cytoband A3.3
Alliance:	Dnase1l2tm1Eckh page

Germline Transmission:	Earliest citation of germline transmission: J:180935
Parent Cell Line:	W4 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion     Exons 2-6 were replaced by a neomycin resistance cassette. (J:180935)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dnase1l2 Mutation:	23 strains or lines available

Original:	J:180935 Fischer H, et al., Essential role of the keratinocyte-specific endonuclease DNase1L2 in the removal of nuclear DNA from hair and nails. J Invest Dermatol. 2011 Jun;131(6):1208-15
All:	4 reference(s)