Summary | Mutation origin | Mutation description | Recombinase activity | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Cd207tm2.1(cre)Bjec
Name:	CD207 antigen; targeted mutation 2.1, Bjorn Clausen
MGI ID:	MGI:5308064
Synonyms:	Langerin-Cre
Gene:	Cd207  Location: Chr6:83648197-83654839 bp, - strand  Genetic Position: Chr6, 35.94 cM, cytoband D1-D2
Alliance:	Cd207tm2.1(cre)Bjec page

Germline Transmission:	Earliest citation of germline transmission: J:179630
Parent Cell Line:	v6.5 (ES Cell)
Strain of Origin:	(C57BL/6 x 129S4/SvJae)F1

Allele Type:    Targeted (Recombinase) Mutation:    Insertion   Cd207tm2.1(cre)Bjec expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Cd207 (MGI:2180021)   Mutation details: A cDNA encoding cre recombinase with a bovine polyadenylation sequence and a nuclear localization signal (NLS) and followed by an Frt-flanked neo cassette was inserted into exon 2 of Cd207 (langerin) by homologous recombination. After verifying germline transmission, the neo resistance cassette was deleted from the allele by breeding founders to FLPe-expressing mice. (J:179630)

Activity:	Tissue activity of this recombinase allele
Driver:	Cd207 (mouse) Summary of all recombinase alleles driven by Cd207. Alliance mouse Cd207 gene page

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cd207 Mutation:	25 strains or lines available

Original:	J:179630 Zahner SP, et al., Conditional deletion of TGF-betaR1 using Langerin-Cre mice results in Langerhans cell deficiency and reduced contact hypersensitivity. J Immunol. 2011 Nov 15;187(10):5069-76
All:	16 reference(s)