Tac2tm1.1(cre)Qima
Targeted Allele Detail
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Symbol: |
Tac2tm1.1(cre)Qima |
Name: |
tachykinin 2; targeted mutation 1.1, Qiufu Ma |
MGI ID: |
MGI:5307922 |
Synonyms: |
Tac2-Cre |
Gene: |
Tac2 Location: Chr10:127560347-127567637 bp, + strand Genetic Position: Chr10, 74.81 cM, cytoband D3
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Alliance: |
Tac2tm1.1(cre)Qima page
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Germline Transmission: |
Earliest citation of germline transmission:
J:180805
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
129/Sv
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Allele Type: |
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Targeted (Recombinase) |
Mutation: |
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Insertion
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Tac2tm1.1(cre)Qima expression driven by
1 gene
Knock-in expression driven by:
Organism |
Driver Gene |
Note |
mouse |
Tac2 (MGI:98476) |
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Mutation details: The cre coding sequence with a poly adenylation signal was inserted in-frame with the first ATG of the Tac2 gene by homologous recombination. The initial targeting vector contained an Frt-flanked neomycin cassette. Germline-transmitting mice were crossed with a Flp deleter strain to excise the neo cassette. Insertion of the cre cassette results in generation of a null allele of Tac2 demonstrated by absence of Tac2 expression in the dorsal spinal cord as detected by in situ hybridization.
(J:180805)
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Activity: |
Tissue activity of this recombinase allele
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Driver:
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Tac2
(mouse)
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View phenotypes and curated references for all genotypes (concatenated display).
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Original: |
J:180805 Mar L, et al., Genetic marking and characterization of Tac2-expressing neurons in the central and peripheral nervous system. Mol Brain. 2012;5:3 |
All: |
7 reference(s) |
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