Summary | Transgene origin | Transgene description | Recombinase activity | Tumor data | Find Mice (IMSR) | References

Symbol:	Tg(Krt8-cre/ERT2)17Blpn
Name:	transgene insertion 17, Cedric Blanpain
MGI ID:	MGI:5305437
Synonyms:	K8-CreER, K8- CreERT2
Transgene:	Tg(Krt8-cre/ERT2)17Blpn  Location: unknown
Alliance:	Tg(Krt8-cre/ERT2)17Blpn page

Strain of Origin:

Not Specified

Transgene Type:    Transgenic (Inducible, Recombinase) Inducer:    tamoxifen Mutation:    Insertion   Tg(Krt8-cre/ERT2)17Blpn expression driven by 1 gene Transgene expression driven by: Organism Driver Gene Note mouse Krt8 (MGI:96705)   Mutation details: A transgene construct containing 3.5 kb of sequence upstream of the ATG start site of the mouse Krt8 gene (purified from BAC clone RP23-254K21), the beta globin intron, SV40 polyadenylation site and a cre/ERT2 segment was injected into C57Bl/6 fertilized eggs. Four of seven founder mice displayed the expected pattern of expression and Founder line 17 was subsequently established. The transgenic animals were then bred to CD1 mice. (J:180048)

Activity:	Tissue activity of this recombinase allele
Driver:	Krt8 (mouse) Summary of all recombinase alleles driven by Krt8. Alliance mouse Krt8 gene page

List all tumor models in MMHCdb carrying Tg(Krt8-cre/ERT2)17Blpn

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:180048 Van Keymeulen A, et al., Distinct stem cells contribute to mammary gland development and maintenance. Nature. 2011 Nov 10;479(7372):189-93
All:	29 reference(s)