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Gene Expression Data
Assay Details
Assay
Reference: J:50138 Niederreither K, et al., Expression of T:G mismatch-specific thymidine-DNA glycosylase and DNA methyl transferase genes during development and tumorigenesis. Oncogene. 1998 Sep 24;17(12):1577-85
Assay type: RNA in situ
MGI Accession ID: MGI:5304437
Gene symbol: Tdg
Gene name: thymine DNA glycosylase
Probe: Tdg cDNA
Probe preparation: Antisense labelled with radioactivity RNA
Results
Specimen Not shown E7.5: embryonic day 7.5 (more )
Structure Level Pattern Image Note
TS11: embryo Present Ubiquitous The authors state that expression was uniform and ubiquitous in all regions of the mouse embryo from 7.5- 13.5.

Specimen Not shown E13.5: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: embryo Present Ubiquitous The authors state that expression was uniform and ubiquitous in all regions of the mouse embryo from 7.5- 13.5.

Specimen 1A: embryonic day 14.5 (more )
Note: brightfield/darkfield pair
Structure Level Pattern Image Note
TS22: adrenal gland Strong 1A
TS22: central nervous system Strong 1A
TS22: intestine Strong 1A
TS22: liver Strong 1A
TS22: lung Strong 1A
TS22: metanephros Strong 1A
TS22: nasal cavity epithelium Strong 1A
TS22: oral epithelium Strong 1A
TS22: peripheral nervous system Strong 1A
TS22: retina Strong 1A
TS22: spinal cord Strong 1A
TS22: thymus primordium Strong 1A
TS22: lobar bronchus epithelium Present 1A
TS22: trachea epithelium Present 1A
TS22: bladder Present Regionally restricted 1A Expression is in bladder epithelium and outer mesenchyme.
TS22: cardiac muscle tissue Weak Regionally restricted 1A

Specimen 1B: embryonic day 14.5 (more )
Note: brightfield/darkfield pair
Structure Level Pattern Image Note
TS22: hindlimb musculature Moderate 1B
TS22: hindlimb cartilage condensation Absent 1B

Specimen 1C: embryonic day 14.5 (more )
Note: brightfield/darkfield pair
Structure Level Pattern Image Note
TS22: lobar bronchus epithelium Present 1C
TS22: thymus primordium Present 1C
TS22: trachea epithelium Present 1C

Specimen 1D: embryonic day 14.5 (more )
Note: brightfield/darkfield pair
Structure Level Pattern Image Note
TS22: intestine epithelium Strong 1D
TS22: intestine mesenchyme Weak 1D

Specimen Not shown, E16.5: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: embryo Present Regionally restricted Expression persisted in most of the structures as seen at E14.5.

Specimen 2B: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: thymus Very strong 2B
TS26: adenohypophysis Strong 2B
TS26: brain Strong 2B
TS26: neural retina Strong 2B
TS26: renal cortex Strong 2B
TS26: spinal cord Strong 2B
TS26: spinal ganglion Strong 2B
TS26: lens epithelium Strong Regionally restricted 2B
TS26: enamel organ Strong Regionally restricted 2B Expression is in the inner enamel epithelium of the developing tooth buds, including the actively dividing ameloblast cells.
TS26: intestine epithelium Strong Regionally restricted 2B Expression is in the most basal cell layer with the strongest expression is in crypt cells.
TS26: skeletal muscle Moderate 2B
TS26: brown fat Moderate Regionally restricted 2B Expression is in the brown fat cells of the neck region.
TS26: cochlear duct epithelium Present 2B
TS26: hair follicle Present 2B
TS26: liver Present 2B
TS26: lung Present 2B
TS26: salivary gland epithelium Present 2B
TS26: vibrissa follicle Present 2B

Specimen 3A: embryonic day 18.5 (more )
Note: brightfield/darkfield pair
Structure Level Pattern Image Note
TS26: lens epithelium Strong 3A
TS26: neural retina Strong 3A
TS26: hair follicle Present 3A

Specimen 3B: embryonic day 18.5 (more )
Note: brightfield/darkfield pair
Structure Level Pattern Image Note
TS26: oral epithelium Present Regionally restricted 3B Expression is in the basal proliferative cell layer.
TS26: tongue epithelium Present Regionally restricted 3B Expression is in the basal proliferative cell layer.
TS26: enamel organ Strong Regionally restricted 3B Expression is in the inner enamel epithelium of the developing tooth buds, including the actively dividing ameloblast cells.
TS26: hair follicle Present 3B
TS26: vibrissa follicle Present 3B

Specimen 3C: embryonic day 18.5 (more )
Note: brightfield/darkfield pair
Structure Level Pattern Image Note
TS26: olfactory epithelium Strong 3C

Specimen 3D: embryonic day 18.5 (more )
Note: brightfield/darkfield pair
Structure Level Pattern Image Note
TS26: intestine epithelium Strong Regionally restricted 3D Expression is in the most basal cell layer with the strongest expression is in crypt cells.

Specimen 3E: embryonic day 18.5 (more )
Note: brightfield/darkfield pair
Structure Level Pattern Image Note
TS26: epidermis Present Regionally restricted 3E Expression is in the proliferative basal layer of the skin epidermis.
TS26: hair follicle Present 3E

Specimen 3F: embryonic day 18.5 (more )
Note: brightfield/darkfield pair
Structure Level Pattern Image Note
TS26: rib Present Regionally restricted 3F Expression is in bones undergoing endochondral ossification: the signal was specific to the bone tissue underlying hypertrophic chondrocytes and to the region of transition between perichondrium and periosteum.

Specimen 4A: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: seminiferous cord Strong 4A TDG
TS26: metanephros Strong Regionally restricted 4A TDG Expression is in the epithelium.

Specimen 4B: postnatal day 10 (more )
Structure Level Pattern Image Note
TS28: seminiferous tubule Strong 4B TDG
TS28: epididymis Strong Regionally restricted 4B TDG Expression is in the epithelium.

Specimen 4C: postnatal day 40 (more )
Structure Level Pattern Image Note
TS28: seminiferous tubule Present 4C TDG
TS28: epididymis Strong Regionally restricted 4C TDG Expression is in the epithelium.

Specimen 4D: postnatal day 40 (more )
Structure Level Pattern Image Note
TS28: ovary antral follicle Strong 4D TDG
TS28: ovary mature follicle Strong 4D TDG
TS28: ovary primary follicle Strong 4D TDG
TS28: corpus luteum Weak 4D TDG
TS28: mesenchymal stroma of ovary Absent 4D TDG
TS28: oocyte Absent 4D TDG

Specimen Not shown, P70: postnatal day 70 (more )
Structure Level Pattern Image Note
TS28: seminiferous tubule Present

Specimen Not shown, P: postnatal (more )
Structure Level Pattern Image Note
TS28: endometrium epithelium Strong
TS28: epithelial layer of oviduct Strong

Specimen 5A: postnatal (more )
Structure Level Pattern Image Note
TS28: mammary gland epithelium Weak 5A TDG Expression is in the lactating mammary gland epithelium.

Specimen 6A: postnatal adult (more )
Structure Level Pattern Image Note
TS28: bone Weak 6A TDG


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/30/2024
MGI 6.23
The Jackson Laboratory