Summary | Mutation origin | Mutation description | Recombinase activity | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Ccn6tm1(cre)Mawa
Name:	cellular communication network factor 6; targeted mutation 1, Matthew L Warman
MGI ID:	MGI:5302829
Synonyms:	Wisp3GFP-Cre, Wisp3tm1(EGFP/cre)Mawa
Gene:	Ccn6  Location: Chr10:39026966-39039790 bp, - strand  Genetic Position: Chr10, 20.19 cM
Alliance:	Ccn6tm1(cre)Mawa page

Germline Transmission:	Earliest citation of germline transmission: J:179652
Parent Cell Line:	v6.5 (ES Cell)
Strain of Origin:	(C57BL/6 x 129S4/SvJae)F1

Allele Type:    Targeted (Recombinase) Mutation:    Insertion   Ccn6tm1(cre)Mawa expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Ccn6 (MGI:2685581)   Mutation details: An EGFP-IRES-cre-construct was introduced to the first exon of Wisp3, retaining the gene's ATG translation initiation site. No full-length Wisp3 transcripts can be detected by RT-PCR. Donating investigator indicates that expression of EGFP (enhanced green fluorescence protein) cannot be visualized by fluorescence microscopy. Hetero- and homozygous mice show no apparent phenotype. When males mutants are crossed with animals carrying a conditional (floxed) allele, cre-mediated recombination is observed in 100% of offspring. (Females occasionally also express cre in germ cells but at the precise stage is unclear. Cre-mediated recombination is observed in 7% of offspring from females.)There is little or no expression of cre in most other tissues examined, including muscle, kidney, bone, liver, and lung. Occasional recombination in brain, cartilage, and heart is seen. (J:179652, J:201718)

Activity:	Tissue activity of this recombinase allele
Driver:	Ccn6 (mouse) Summary of all recombinase alleles driven by Ccn6. Alliance mouse Ccn6 gene page

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ccn6 Mutation:	23 strains or lines available

Original:	J:179652 Warman ML, Generation of a knock-in cre recombinase allele of Wisp3. MGI Direct Data Submission. 2012;
All:	3 reference(s)