Lzts2tm1.1Zsu
Targeted Allele Detail
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Symbol: |
Lzts2tm1.1Zsu |
Name: |
leucine zipper, putative tumor suppressor 2; targeted mutation 1.1, Zijie Sun |
MGI ID: |
MGI:5302222 |
Synonyms: |
Lzts2- |
Gene: |
Lzts2 Location: Chr19:45003615-45015554 bp, + strand Genetic Position: Chr19, 38.2 cM
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Alliance: |
Lzts2tm1.1Zsu page
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Lzts2tm1.1Zsu/Lzts2tm1.1Zsu mice exhibit kidney and urinary tract anomalies
Show the 3 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:178154
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Parent Cell Line: |
iTL BA1 (ES Cell)
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Strain of Origin: |
(C57BL/6NTac x 129S6/SvEvTac)F1
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A loxP and FRT flanked neo cassette was inserted upstream of exon 2 and a loxP site was inserted downstream of exon 3 via homologous recombination. Recombinase mediated recombination removed the neo cassette and exons 2 and 3. Western blot analysis confirmed the absence of protein expression in homozygous embryos.
(J:178154)
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Generation of the Lzts2tm1.1Zsu allele |
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Lzts2 Mutation: |
14 strains or lines available
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Original: |
J:178154 Peng Y, et al., The Leucine Zipper Putative Tumor Suppressor 2 Protein LZTS2 Regulates Kidney Development. J Biol Chem. 2011 Nov 18;286(46):40331-42 |
All: |
3 reference(s) |
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