Summary | Transgene origin | Transgene description | Find Mice (IMSR) | References

Symbol:	Tg(Rho-Sag*)50Seva
Name:	transgene insertion 50, Vsevolod Gurevich
MGI ID:	MGI:5301173
Synonyms:	3A-50, Tg(Rho-Sag*)1Seva, Tg(Sag*3A50)1Seva
Transgene:	Tg(Rho-Sag*)50Seva  Location: unknown
Alliance:	Tg(Rho-Sag*)50Seva page

Strain of Origin:

C57BL/6

Transgene Type:    Transgenic (Inserted expressed sequence) Mutation:    Insertion   Tg(Rho-Sag*)50Seva expresses 1 gene Transgene expresses: Organism Expressed Gene Note mouse Sag (MGI:98227)   Mutation details: The transgenic construct contains three amino acid substitutions (Leu374Ala, Val375Ala, and Phe376Ala) introduced into the mouse retinal S-antigen (arrestin; (GenBank M24086)) coding sequence under the direction of the mouse rod opsin promoter. Line 1 and 2 with moderate and high expression were generated from founders 3A50 and 3A240, respectively. (J:99855)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:99855 Nair KS, et al., Light-dependent redistribution of arrestin in vertebrate rods is an energy-independent process governed by protein-protein interactions. Neuron. 2005 May 19;46(4):555-67
All:	5 reference(s)