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Gene Expression Data
Assay Details
Assay
Reference: J:166449 Nishino J, et al., Lgi4 promotes the proliferation and differentiation of glial lineage cells throughout the developing peripheral nervous system. J Neurosci. 2010 Nov 10;30(45):15228-40
Assay type: Immunohistochemistry
MGI Accession ID: MGI:5301122
Gene symbol: Gfap
Gene name: glial fibrillary acidic protein
Antibody: anti-GFAP
Detection system: Secondary antibody coupled to Alexa Fluor 488
Results
Specimen 6B top left: postnatal day 0 (more )
Note: Whole mount of the outer plexus/muscle layers from the gut.
Structure Level Pattern Image Note
TS27: myenteric nerve plexus Present Regionally restricted 6B top left Expressed in glial cells.
Specimen 6B top right: postnatal day 0; Lgi4tm1Sjm/Lgi4tm1Sjm (more )
Note: Whole mount of the outer plexus/muscle layers from the gut.
Structure Level Pattern Image Note
TS27: myenteric nerve plexus Present Regionally restricted 6B top right Greatly reduced expression in glial cells, which were smaller and with fewer processes, compared with controls.
Specimen 6C bottom left: postnatal day 4 (more )
Note: Double labeled: green - Gfap; red - Rbfox3 (assay MGI:5300959).
Structure Level Pattern Image Note
TS28: dorsal root ganglion Present Regionally restricted 6C bottom left Expressed in satellite glia.
Specimen 6C bottom right: postnatal day 4; Lgi4tm1Sjm/Lgi4tm1Sjm (more )
Note: Double labeled: green - Gfap; red - Rbfox3 (assay MGI:5300959).
Structure Level Pattern Image Note
TS28: dorsal root ganglion Present Regionally restricted 6C bottom right Sparse positive satellite glia, with fewer processes compared with controls.
Specimen 6D bottom left: postnatal day 4 (more )
Note: Double labeled: green - Gfap; red - Rbfox3 (assay MGI:5300959).
Structure Level Pattern Image Note
TS28: sympathetic ganglion Present Regionally restricted 6D bottom left Expressed in satellite glia.
Specimen 6D bottom right: postnatal day 4; Lgi4tm1Sjm/Lgi4tm1Sjm (more )
Note: Double labeled: green - Gfap; red - Rbfox3 (assay MGI:5300959).
Structure Level Pattern Image Note
TS28: sympathetic ganglion Present Regionally restricted 6D bottom right Sparse positive satellite glia, with fewer processes compared with controls.
Specimen S4 GFAP wt: postnatal day 4 (more )
Note: Double labeled: green - Gfap; red - Rbfox3 (assay MGI:5300959).
Structure Level Pattern Image Note
TS28: dorsal root ganglion Present Regionally restricted S4_GFAP wt , S4_Merged wt Expressed in satellite glia. Present in a honeycomb-like pattern.
Specimen S4 GFAP mut: postnatal day 4; Lgi4tm1Sjm/Lgi4tm1Sjm (more )
Note: Double labeled: green - Gfap; red - Rbfox3 (assay MGI:5300959).
Structure Level Pattern Image Note
TS28: dorsal root ganglion Present Regionally restricted S4_Merged mut , S4_GFAP mut Sparse positive satellite glia, with fewer processes compared with controls. Unlike in control, no honeycomb-like pattern was evident.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/30/2024
MGI 6.23 		The Jackson Laboratory