Tg(Col1a1-Hsd11b2)Bek
Transgene Detail
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| Symbol: |
Tg(Col1a1-Hsd11b2)Bek |
| Name: |
transgene insertion, Barbara E Kream |
| MGI ID: |
MGI:5300940 |
| Synonyms: |
Col2.3-HSD2 |
| Transgene: |
Tg(Col1a1-Hsd11b2)Bek Location: unknown
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| Alliance: |
Tg(Col1a1-Hsd11b2)Bek page
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| Transgene Type: |
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Transgenic (Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(Col1a1-Hsd11b2)Bek expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Homolog in Mouse |
Note |
| rat |
Hsd11b2 (25117) |
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Mutation details: The transgenic construct contains rat 11beta-HSD2 cDNA (Hsd11b2) gene, and was cloned downstream of a 2.3-kb fragment of the rat Col1a1 promoter and upstream of the bovine GH polyadenylation sequence. Three independent lines were established, 515, 516 and 529. The transgene was expressed in calvariae, long bone, vertebrae, and tail of transgenic mice.
(J:96387)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:96387 Sher LB, et al., Transgenic expression of 11beta-hydroxysteroid dehydrogenase type 2 in osteoblasts reveals an anabolic role for endogenous glucocorticoids in bone. Endocrinology. 2004 Feb;145(2):922-9 |
| All: |
6 reference(s) |
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Analysis Tools
