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Gene Expression Data
Assay Details
Assay
Reference: J:166449 Nishino J, et al., Lgi4 promotes the proliferation and differentiation of glial lineage cells throughout the developing peripheral nervous system. J Neurosci. 2010 Nov 10;30(45):15228-40
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:5300916
Gene symbol: Lgi4
Gene name: leucine-rich repeat LGI family, member 4
Reporter: lacZ
Direct Detection
Assay notes: Fixed with 1% paraformaldehyde/0.2% glutaraldehyde.
Results
Specimen 1A left: embryonic day 9.5; Lgi4tm1Sjm/Lgi4+ (more )
Structure Level Pattern Image Note
TS15: migrating neural crest Present 1A left Expressed by migrating trunk neural crest cells.
Specimen 1B left: embryonic day 10.5; Lgi4tm1Sjm/Lgi4+ (more )
Structure Level Pattern Image Note
TS17: cranial ganglion Present 1B left
TS17: dorsal root ganglion Present 1B left
TS17: facial ganglion Present 1B left
TS17: trigeminal ganglion Present 1B left
TS17: migrating neural crest Present 1B left Expressed by migrating neural crest cells.
TS17: spinal nerve Present 1B left Peripheral nerves.
TS17: sympathetic nervous system Present 1B left Sympathetic ganglia.
Specimen 1B middle: embryonic day 10.5; Lgi4tm1Sjm/Lgi4+ (more )
Structure Level Pattern Image Note
TS17: dorsal root ganglion Present 1B middle
TS17: sympathetic nervous system Present 1B middle Sympathetic ganglia.
TS17: migrating neural crest Present 1B middle Expressed by migrating neural crest cells within the gut.
Specimen 1C Gut - E13.5: embryonic day 13.5; Lgi4tm1Sjm/Lgi4+ (more )
Structure Level Pattern Image Note
TS21: enteric nervous system Present 1C E13.5 Gut Expression in the myenteric plexus of the gut.
Specimen 1C DRG - E13.5: embryonic day 13.5; Lgi4tm1Sjm/Lgi4+ (more )
Structure Level Pattern Image Note
TS21: dorsal root ganglion Present 1C E13.5 DRG
Specimen 1C Sym.g. - E13.5: embryonic day 13.5; Lgi4tm1Sjm/Lgi4+ (more )
Structure Level Pattern Image Note
TS21: sympathetic ganglion Present 1C E13.5 Sym.g.
Specimen 1C Nerve - E13.5: embryonic day 13.5; Lgi4tm1Sjm/Lgi4+ (more )
Structure Level Pattern Image Note
TS21: spinal nerve Present 1C E13.5 Nerve Peripheral nerves.
Specimen 1C Parasym. g - E13.5: embryonic day 13.5; Lgi4tm1Sjm/Lgi4+ (more )
Structure Level Pattern Image Note
TS21: parasympathetic nervous system Present 1C E13.5 Parasym. g Expression in parasympathetic ganglia.
Specimen 1C Gut - P0: postnatal day 0; Lgi4tm1Sjm/Lgi4+ (more )
Structure Level Pattern Image Note
TS27: myenteric nerve plexus Present 1C P0 Gut Bacterial LacZ activity in the lumen is seen similar to wild type control.
Specimen 1C DRG - P0: postnatal day 0; Lgi4tm1Sjm/Lgi4+ (more )
Structure Level Pattern Image Note
TS27: dorsal root ganglion Present Regionally restricted 1C P0 DRG Reduced expression relative to E13.5, restricted to a subpopulation of cells in each ganglion.
Specimen 1C Sym.g. - P0: postnatal day 0; Lgi4tm1Sjm/Lgi4+ (more )
Structure Level Pattern Image Note
TS27: sympathetic ganglion Present 1C P0 Sym.g. Expression in sympathetic ganglion, including the celiac ganglion.
Specimen 1C Nerve - P0: postnatal day 0; Lgi4tm1Sjm/Lgi4+ (more )
Structure Level Pattern Image Note
TS27: peripheral nerve Present 1C P0 Nerve
Specimen 1C Parasym. g - P0: postnatal day 0; Lgi4tm1Sjm/Lgi4+ (more )
Structure Level Pattern Image Note
TS27: parasympathetic ganglion Present 1C P0 Parasym. g
Specimen 6A middle: postnatal day 0; Lgi4tm1Sjm/Lgi4+ (more )
Note: Whole mount of the outer plexus/muscle layers from the gut.
Structure Level Pattern Image Note
TS27: myenteric nerve plexus Present 6A middle Expressed in dense, mesh-like myenteric plexus.
Specimen 6A bottom: postnatal day 0; Lgi4tm1Sjm/Lgi4tm1Sjm (more )
Note: Whole mount of the outer plexus/muscle layers from the gut.
Structure Level Pattern Image Note
TS27: myenteric nerve plexus Present 6A bottom Expressed in sparse myenteric plexus with fewer connections among ganglia.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
MGI 6.24 		The Jackson Laboratory