About   Help   FAQ
Gene Expression Data
Assay Details
Assay
Reference: J:166449 Nishino J, et al., Lgi4 promotes the proliferation and differentiation of glial lineage cells throughout the developing peripheral nervous system. J Neurosci. 2010 Nov 10;30(45):15228-40
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:5300916
Gene symbol: Lgi4
Gene name: leucine-rich repeat LGI family, member 4
Reporter: lacZ
Direct Detection
Assay notes: Fixed with 1% paraformaldehyde/0.2% glutaraldehyde.
Results
Specimen 1A left: embryonic day 9.5; Lgi4tm1Sjm/Lgi4+ (more )
Structure Level Pattern Image Note
TS15: migrating neural crest Present 1A left Expressed by migrating trunk neural crest cells.

Specimen 1B left: embryonic day 10.5; Lgi4tm1Sjm/Lgi4+ (more )
Structure Level Pattern Image Note
TS17: cranial ganglion Present 1B left
TS17: dorsal root ganglion Present 1B left
TS17: facial ganglion Present 1B left
TS17: trigeminal ganglion Present 1B left
TS17: migrating neural crest Present 1B left Expressed by migrating neural crest cells.
TS17: spinal nerve Present 1B left Peripheral nerves.
TS17: sympathetic nervous system Present 1B left Sympathetic ganglia.

Specimen 1B middle: embryonic day 10.5; Lgi4tm1Sjm/Lgi4+ (more )
Structure Level Pattern Image Note
TS17: dorsal root ganglion Present 1B middle
TS17: sympathetic nervous system Present 1B middle Sympathetic ganglia.
TS17: migrating neural crest Present 1B middle Expressed by migrating neural crest cells within the gut.

Specimen 1C Gut - E13.5: embryonic day 13.5; Lgi4tm1Sjm/Lgi4+ (more )
Structure Level Pattern Image Note
TS21: enteric nervous system Present 1C E13.5 Gut Expression in the myenteric plexus of the gut.

Specimen 1C DRG - E13.5: embryonic day 13.5; Lgi4tm1Sjm/Lgi4+ (more )
Structure Level Pattern Image Note
TS21: dorsal root ganglion Present 1C E13.5 DRG

Specimen 1C Sym.g. - E13.5: embryonic day 13.5; Lgi4tm1Sjm/Lgi4+ (more )
Structure Level Pattern Image Note
TS21: sympathetic ganglion Present 1C E13.5 Sym.g.

Specimen 1C Nerve - E13.5: embryonic day 13.5; Lgi4tm1Sjm/Lgi4+ (more )
Structure Level Pattern Image Note
TS21: spinal nerve Present 1C E13.5 Nerve Peripheral nerves.

Specimen 1C Parasym. g - E13.5: embryonic day 13.5; Lgi4tm1Sjm/Lgi4+ (more )
Structure Level Pattern Image Note
TS21: parasympathetic nervous system Present 1C E13.5 Parasym. g Expression in parasympathetic ganglia.

Specimen 1C Gut - P0: postnatal day 0; Lgi4tm1Sjm/Lgi4+ (more )
Structure Level Pattern Image Note
TS27: myenteric nerve plexus Present 1C P0 Gut Bacterial LacZ activity in the lumen is seen similar to wild type control.

Specimen 1C DRG - P0: postnatal day 0; Lgi4tm1Sjm/Lgi4+ (more )
Structure Level Pattern Image Note
TS27: dorsal root ganglion Present Regionally restricted 1C P0 DRG Reduced expression relative to E13.5, restricted to a subpopulation of cells in each ganglion.

Specimen 1C Sym.g. - P0: postnatal day 0; Lgi4tm1Sjm/Lgi4+ (more )
Structure Level Pattern Image Note
TS27: sympathetic ganglion Present 1C P0 Sym.g. Expression in sympathetic ganglion, including the celiac ganglion.

Specimen 1C Nerve - P0: postnatal day 0; Lgi4tm1Sjm/Lgi4+ (more )
Structure Level Pattern Image Note
TS27: peripheral nerve Present 1C P0 Nerve

Specimen 1C Parasym. g - P0: postnatal day 0; Lgi4tm1Sjm/Lgi4+ (more )
Structure Level Pattern Image Note
TS27: parasympathetic ganglion Present 1C P0 Parasym. g

Specimen 6A middle: postnatal day 0; Lgi4tm1Sjm/Lgi4+ (more )
Note: Whole mount of the outer plexus/muscle layers from the gut.
Structure Level Pattern Image Note
TS27: myenteric nerve plexus Present 6A middle Expressed in dense, mesh-like myenteric plexus.

Specimen 6A bottom: postnatal day 0; Lgi4tm1Sjm/Lgi4tm1Sjm (more )
Note: Whole mount of the outer plexus/muscle layers from the gut.
Structure Level Pattern Image Note
TS27: myenteric nerve plexus Present 6A bottom Expressed in sparse myenteric plexus with fewer connections among ganglia.


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
04/16/2024
MGI 6.23
The Jackson Laboratory