Summary | Mutation origin | Mutation description | Recombinase activity | Phenotypes | Find Mice (IMSR) | References

Symbol:	Hopxtm2.1(cre/ERT2)Joe
Name:	HOP homeobox; targeted mutation 2.1, Jonathan A Epstein
MGI ID:	MGI:5300731
Synonyms:	HopxERCre
Gene:	Hopx  Location: Chr5:77234835-77262968 bp, - strand  Genetic Position: Chr5, 41.45 cM
Alliance:	Hopxtm2.1(cre/ERT2)Joe page

Germline Transmission:	Earliest citation of germline transmission: J:178296
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129

Allele Type:    Targeted (Inducible, Recombinase) Inducer:    tamoxifen Mutation:    Insertion   Hopxtm2.1(cre/ERT2)Joe expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Hopx (MGI:1916782)   Mutation details: An IRES-cre/ERT-Frt-PGK-neo-Frt cassette was inserted into the 3' UTR of the Hopx locus by homologous recombination in ES cells. Subsequently, these animals were crossed to mice expressing the Tg(ACTFLPe)9205Dym recombinase allele to remove the PGK-neo cassette. (J:178296)

Activity:	Tissue activity of this recombinase allele
Driver:	Hopx (mouse) Summary of all recombinase alleles driven by Hopx. Comparative matrix view of recombinase activities Alliance mouse Hopx gene page

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Hopx Mutation:	11 strains or lines available

Original:	J:178296 Takeda N, et al., Interconversion between intestinal stem cell populations in distinct niches. Science. 2011 Dec 9;334(6061):1420-4
All:	31 reference(s)