Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Skor2Tn(sb-Tyr)1799B.CA7BOve
Name:	SKI family transcriptional corepressor 2; transposon insertion 1799B.CA7B, Paul A Overbeek
MGI ID:	MGI:5300201
Synonyms:	OVE1799B-CA7B
Gene:	Skor2  Location: Chr18:76944100-76988037 bp, + strand  Genetic Position: Chr18, 51.93 cM
Alliance:	Skor2Tn(sb-Tyr)1799B.CA7BOve page

Strain of Origin:

FVB/N

Allele Type:    Transposon induced (Inserted expressed sequence) Mutations:    Intragenic deletion, Transposon insertion   Mutation details: Mobilization of TgTn(sb-Tyr)1799BOve with Sleeping Beauty transposase from Tg(CAG-sb10)1Dla results in the integration of the transposon in a non-coding region 237 kbp upstream from the start codon of Skor2 [NCB137/mm9; 76,860,053] through intron 8 of Skor2 [NCB137/mm9; 77,133,014] deleting exons 1 through 8. Real-time RT-PCR confirmed the absence of transcript expression in the P0 cerebellum. (J:178818)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Skor2 Mutation:	45 strains or lines available

Original:	J:178818 Wang B, et al., Transposon mutagenesis with coat color genotyping identifies an essential role for Skor2 in sonic hedgehog signaling and cerebellum development. Development. 2011 Oct;138(20):4487-97
All:	2 reference(s)