Tg(Vsx2-cre)2690Chow
Transgene Detail
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| Symbol: |
Tg(Vsx2-cre)2690Chow |
| Name: |
transgene insertion 2690, Robert L Chow |
| MGI ID: |
MGI:5297524 |
| Synonyms: |
Vsx2-5.3-PRE-Cre |
| Transgene: |
Tg(Vsx2-cre)2690Chow Location: unknown
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| Alliance: |
Tg(Vsx2-cre)2690Chow page
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| Strain of Origin: |
C57BL/6 x C3H
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| Transgene Type: |
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Transgenic (Recombinase) |
| Mutation: |
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Insertion
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Tg(Vsx2-cre)2690Chow expression driven by
1 gene
Transgene expression driven by:
| Organism |
Driver Gene |
Note |
| Not Specified |
Vsx2 |
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Mutation details: Cre recombinase cDNA was cloned downstream of a 5.3kb upstream region of the Vsx2 gene. A 1.9 kb region containing a 164 bp bipolar enhancer was cloned 5' of the 5.3 kb region. An SV40 polyadenylation sequence was inserted downstream of cre. The 1.9 kb region has been identified as a putative retinal enhancer (PRE) and lies within a conserved non-coding region that is within the breakpoint of the Vsx2 (ocular retardation 2J) mutation. 6 founder lines carried the transgene, with 4 (2690, 2695, 2700, and 2717) exhibiting cre expression detected by immunolabeling.
(J:178063)
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Activity: |
 Tissue activity of this recombinase allele
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Driver:
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Vsx2
(species not specified)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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| Original: |
J:178063 Nickerson PE, et al., A transgenic mouse line expressing cre recombinase in undifferentiated postmitotic mouse retinal bipolar cell precursors. PLoS One. 2011;6(10):e27145 |
| All: |
7 reference(s) |
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Analysis Tools
