Summary | Transgene origin | Transgene description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Tg(Plp1-cre)F627Rako
Name:	transgene insertion F627, Rashmi Kothary
MGI ID:	MGI:5297408
Synonyms:	Plp-Cre line F627
Transgene:	Tg(Plp1-cre)F627Rako  Location: unknown
Alliance:	Tg(Plp1-cre)F627Rako page

Strain of Origin:

Not Specified

Transgene Type:    Transgenic (Recombinase) Mutation:    Insertion   Tg(Plp1-cre)F627Rako expression driven by 1 gene Transgene expression driven by: Organism Driver Gene Note mouse Plp1 (MGI:97623)   Mutation details: Cre cDNA was inserted into a Plp1 promoter cassette consisting of exon 1 and intron 1 of the mouse Plp1 gene. The transgene construct was microinjected into 1-cell embryos. 6/29 founders were positive for the transgene and 2 showed successful germline transmission. Lines F627 showed a wider expression pattern at P4 by RT-PCR with transcripts detected in spinal cord, cerebellum, and cortex and additionally in liver, kidney and tibialis anterior muscle. At P28, only CNS expression was detected. (J:172435)

Activity:	Tissue activity of this recombinase allele
Driver:	Plp1 (mouse) Summary of all recombinase alleles driven by Plp1. Alliance mouse Plp1 gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available

Original:	J:172435 Michalski JP, et al., The Proteolipid Protein Promoter Drives Expression outside of the Oligodendrocyte Lineage during Embryonic and Early Postnatal Development. PLoS One. 2011;6(5):e19772
All:	1 reference(s)