Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Gab2tm4.1Thir
Name:	growth factor receptor bound protein 2-associated protein 2; targeted mutation 4.1, Toshio Hirano
MGI ID:	MGI:5297248
Synonyms:	Gab2deltaPI3K
Gene:	Gab2  Location: Chr7:96730958-96958158 bp, + strand  Genetic Position: Chr7, 53.39 cM, cytoband E2
Alliance:	Gab2tm4.1Thir page

Germline Transmission:	Earliest citation of germline transmission: J:178045
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	C57BL/6Jcl x 129T/SvJcl

Allele Type:    Targeted (Hypomorph) Mutations:    Insertion, Nucleotide substitutions   Mutation details: A cDNA encoding amino acids 89-665 was inserted into exon 2, in which nucleotide substitutions that results in the amino acid substitution of phenylalanine for tyrosine at positions 441, 465, and 573 (Y441F, Y465F, Y573F) abolishing the PI3K-binding domain. A floxed neo cassette inserted downstream of exon 2 was removed by cre-mediated recombination. (J:178045)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gab2 Mutation:	37 strains or lines available

Original:	J:178045 Nishida K, et al., Gab2, via PI-3K, regulates ARF1 in FcepsilonRI-mediated granule translocation and mast cell degranulation. J Immunol. 2011 Jul 15;187(2):932-41
All:	1 reference(s)