Summary | Mutation origin | Mutation description | Recombinase activity | Phenotypes | Find Mice (IMSR) | References

Symbol:	Airetm1.1(cre)Ghr
Name:	autoimmune regulator; targeted mutation 1.1, Georg A Hollander
MGI ID:	MGI:5296650
Gene:	Aire  Location: Chr10:77865856-77879444 bp, - strand  Genetic Position: Chr10, 39.72 cM
Alliance:	Airetm1.1(cre)Ghr page

Germline Transmission:	Earliest citation of germline transmission: J:176844
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Recombinase) Mutations:    Insertion, Intragenic deletion   Airetm1.1(cre)Ghr expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Aire (MGI:1338803)   Mutation details: A cassette composed of an NLS-cre, an IRES-GFP, and an FRT flanked PGK-neomycin replaced exon 1. Flp mediated deletion in-vivo removed the neo selection cassette. (J:176844)

Activity:	Tissue activity of this recombinase allele
Driver:	Aire (mouse) Summary of all recombinase alleles driven by Aire. Alliance mouse Aire gene page

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Aire Mutation:	52 strains or lines available

Original:	J:176844 Lei Y, et al., Aire-dependent production of XCL1 mediates medullary accumulation of thymic dendritic cells and contributes to regulatory T cell development. J Exp Med. 2011 Feb 14;208(2):383-94
All:	2 reference(s)