Tg(Kdr-TVA)1026Ebp Transgene Detail MGI Mouse (MGI:5296521)

Tg(Kdr-TVA)1026Ebp
Transgene Detail

Summary

Symbol:	Tg(Kdr-TVA)1026Ebp
Name:	transgene insertion 1026, Elena Pasquale
MGI ID:	MGI:5296521
Synonyms:	Flk1-TVA
Transgene:	Tg(Kdr-TVA)1026Ebp Location: unknown
Alliance:	Tg(Kdr-TVA)1026Ebp page

Transgene
origin

Strain of Origin:

FVB/N

Transgene
description

Transgene Type:		Transgenic (Inserted expressed sequence)
Mutation:		Insertion
		Mutation details: A 786-nucleotide cDNA (nucleotides 34-819 of pg800) encoding the quail receptor (TVA) for avian leukosis viruses of subgroup A [ALV(A)] is expressed under the control of regulatory sequences from the mouse Kdr (kinase insert domain protein receptor) gene: a -640 bp to +299 bp genomic DNA fragment containing the promoter and a 2.3 kb fragment containing the endothelium-specific enhancer from the first intron. Embryonic day (E) 10.5 embryos of this line were shown by whole mount in situ hybridization to express TVA mRNA selectively in the developing vasculature, in a pattern similar to that of endogenous Kdr mRNA. Only endothelial cells of new vasculature induced in adult mice exhibit strong TVA immunoreactivity. (J:134089)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

Proliferating endothelial cells of new vasculature induced by extracellular matrix implants or by tumors in adult mice bearing this transgene are susceptible to infection by Rous sarcoma virus derived RCAS (replication-competent, avian leukosis virus LTR, splice acceptor) avian retroviral expression vectors, demonstrated by expression specifically in these cells of green fluorescent protein from one such vector. (J:134089)

References

Original:	J:134089 Vervoort VS, et al., A novel Flk1-TVA transgenic mouse model for gene delivery to angiogenic vasculature. Transgenic Res. 2008 Jun;17(3):403-15
All:	1 reference(s)

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