Summary | Transgene origin | Transgene description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Tg(Il9-cre)#Stck
Name:	transgene insertion, Brigitta Stockinger
MGI ID:	MGI:5296240
Synonyms:	Il9Cre
Transgene:	Tg(Il9-cre)#Stck  Location: unknown
Alliance:	Tg(Il9-cre)#Stck page

Strain of Origin:

(CBA x C57BL/10)F1

Transgene Type:    Transgenic (Recombinase) Mutation:    Insertion   Tg(Il9-cre)#Stck expression driven by 1 gene Transgene expression driven by: Organism Driver Gene Note mouse Il9 (MGI:96563)   Mutation details: A targeting construct containing a cre-IRES-mCherry sequence was inserted upstream of the ATG translation initiation site of Il9 via homologous recombination into a BAC clone (RP24-282A18). The recombined BAC was injected into fertilized (CBA x B10)F1 oocytes. Analyses of T cells isolated from crosses to ROSA26-EYFP mice identified only 10% of Il9-producing cells were marked by EYFP. It was discovered that the IRES and mCherry in the construct was disabled because of a premature translational start site in the IRES sequence which possibly diminished activity from the ATG of mCherry sequence. (J:177640)

Activity:	Tissue activity of this recombinase allele
Driver:	Il9 (mouse) Summary of all recombinase alleles driven by Il9. Alliance mouse Il9 gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:177640 Wilhelm C, et al., An IL-9 fate reporter demonstrates the induction of an innate IL-9 response in lung inflammation. Nat Immunol. 2011;12(11):1071-7
All:	2 reference(s)