Tg(Gfap-Il12b)GFp40Ilc
Transgene Detail
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| Symbol: |
Tg(Gfap-Il12b)GFp40Ilc |
| Name: |
transgene insertion GFp40, Iain L Campbell |
| MGI ID: |
MGI:2447492 |
| Synonyms: |
GF-p40 |
| Transgene: |
Tg(Gfap-Il12b)GFp40Ilc Location: unknown
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| Alliance: |
Tg(Gfap-Il12b)GFp40Ilc page
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| Strain of Origin: |
(C57BL/6J x SJL)F1
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| Transgene Type: |
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Transgenic (Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(Gfap-Il12b)GFp40Ilc expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Note |
| mouse |
Il12b (MGI:96540) |
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Mutation details: The transgene consists of a mouse IL12b sequence (nucleotides 1-1055) under the control of a mouse Gfap promoter. The mouse Gfap promoter was used to drive transgene expression in astrocytes. A human growth hormone polyadenylation sequence and SV40 splice donor/acceptor site were also included in the construct.
(J:72989)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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One transgenic animals carrying only the Tg(Gfap-IL12b)2Ilc transgene was created and used to establish a transgenic line. This line is referred to as the GF-p40 line.
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| Original: |
J:72989 Pagenstecher A, et al., Astrocyte-targeted expression of IL-12 induces active cellular immune responses in the central nervous system and modulates experimental allergic encephalomyelitis. J Immunol. 2000 May 1;164(9):4481-92 |
| All: |
2 reference(s) |
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Analysis Tools
