Tg(Gfap-Il12a,Gfap-Il12b)GFIl12Ilc
Transgene Detail
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| Symbol: |
Tg(Gfap-Il12a,Gfap-Il12b)GFIl12Ilc |
| Name: |
transgene insertion GFIl12, Iain L Campbell |
| MGI ID: |
MGI:2447485 |
| Synonyms: |
GF-IL-12 |
| Transgene: |
Tg(Gfap-Il12a,Gfap-Il12b)GFIl12Ilc Location: unknown
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| Alliance: |
Tg(Gfap-Il12a,Gfap-Il12b)GFIl12Ilc page
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| Strain of Origin: |
(C57BL/6J x SJL)F1
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| Transgene Type: |
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Transgenic (Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(Gfap-Il12a,Gfap-Il12b)GFIl12Ilc expresses
2 genes
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Mutation details: In this transgenic line, two constructs were coinjected and cointegrated in the genome. The first construct consists of a mouse IL12a sequence (nucleotides 14-819) under the control of a mouse Gfap promoter. The second construct consists of a mouse IL12b sequence (nucleotides 1-1055) under the control of a mouse Gfap promoter. The mouse Gfap promoter was used to drive transgene expression in astrocytes. A human growth hormone polyadenylation sequence and SV40 splice donor/acceptor site were also included in the constructs.
(J:72989)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Transgenic animals carried insertions for both Tg(Gfap-Il12a)1Ilc and Tg(Gfap-Il12b)1Ilc. These animals were used to establish a stable bigenic line referred to as the GF-IL-12 line.
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| Original: |
J:72989 Pagenstecher A, et al., Astrocyte-targeted expression of IL-12 induces active cellular immune responses in the central nervous system and modulates experimental allergic encephalomyelitis. J Immunol. 2000 May 1;164(9):4481-92 |
| All: |
9 reference(s) |
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Analysis Tools
