Tg(tetO-SNCA*A53T)33Vle
Transgene Detail
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Symbol: |
Tg(tetO-SNCA*A53T)33Vle |
Name: |
transgene insertion 33, Virginia M-Y Lee |
MGI ID: |
MGI:5289968 |
Synonyms: |
tetP-A53Talpha-syn |
Transgene: |
Tg(tetO-SNCA*A53T)33Vle Location: unknown
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Alliance: |
Tg(tetO-SNCA*A53T)33Vle page
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Transgene Type: |
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Transgenic (Humanized sequence, Inducible, Inserted expressed sequence) |
Inducer: |
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doxycycline/tetracycline |
Mutation: |
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Insertion
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Tg(tetO-SNCA*A53T)33Vle expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
SNCA (6622) |
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Mutation details: This transgene consists of the human alpha-synuclein cDNA encoding a mutated protein with an Ala53Thr mutation under the control of the tetracycline responsive promoter. The mutant alpha-synuclein is expressed only in the presence of the tetracycline transactivator (tTA), expressed from a second transgene; administration of doxycycline inhibits tTA binding to tetO, thus suppressing alpha-synuclein expression.
(J:156801)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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Original: |
J:156801 Lim Y, et al., Forebrain overexpression of alpha-synuclein leads to early postnatal hippocampal neuron loss and synaptic disruption. Exp Neurol. 2010 Jan;221(1):86-97 |
All: |
2 reference(s) |
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