Tg(tetO-Gnai2*,-lacZ)382Kndl
Transgene Detail
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| Symbol: |
Tg(tetO-Gnai2*,-lacZ)382Kndl |
| Name: |
transgene insertion 382, Eric R Kandel |
| MGI ID: |
MGI:5289796 |
| Synonyms: |
Tg(tetO-Gnai2*,-lacZ)1Kndl |
| Transgene: |
Tg(tetO-Gnai2*,-lacZ)382Kndl Location: unknown
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| Alliance: |
Tg(tetO-Gnai2*,-lacZ)382Kndl page
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| Transgene Type: |
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Transgenic (Constitutively active, Inducible, Inserted expressed sequence, Reporter) |
| Inducer: |
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doxycycline/tetracycline |
| Mutation: |
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Insertion
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Tg(tetO-Gnai2*,-lacZ)382Kndl expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Note |
| mouse |
Gnai2 (MGI:95772) |
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Mutation details: A cysteine to arginine amino acid substitution at residue 179 (R179C) of the Gnai2 sequence interferes with the ability of the mutant protein to hydrolyze GTP, rendering it constitutively active. This mutant form of the gene was placed under the control of the tetO promoter in these transgenic mice. A second construct expressing bacterial beta-galactosidase (lacZ) under the regulation of a tetO promoter was coinjected with the Gnai2 vector.
(J:109030)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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| Original: |
J:109030 Nicholls RE, et al., mGluR2 acts through inhibitory Galpha subunits to regulate transmission and long-term plasticity at hippocampal mossy fiber-CA3 synapses. Proc Natl Acad Sci U S A. 2006 Apr 18;103(16):6380-5 |
| All: |
2 reference(s) |
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Analysis Tools
