Summary | Transgene origin | Transgene description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Mrpl41Tg(Tyr)2356A-2b1Ove
Name:	mitochondrial ribosomal protein L41; transgene lentiviral insertion 2356A-2b1, Paul A Overbeek
MGI ID:	MGI:5286665
Synonyms:	OVE#2356A-2b1, OVE2356A-2b1
Gene:	Mrpl41  Location: Chr2:24864129-24865110 bp, - strand  Genetic Position: Chr2, 16.88 cM
Alliance:	Mrpl41Tg(Tyr)2356A-2b1Ove page

Strain of Origin:

FVB/N

Transgene Type:    Transgenic (Reporter) Mutation:    Insertion   Mutation details: The Tyro-IRES-sd-loxP-FUGW lentiviral transgene (LV2187) was designed with a mouse tyrosinase minigene (Tyro) followed by an IRES::3xATG::splice-donor::loxP sequence in the FUGW self-inactivating HIV-based lentiviral vector backbone. The Tyro-IRES-sd-loxP replaced the ubiquitin-c promoter, EGFP, and WPRE sequences originally found in the FUGW lentiviral vector. The Tyro minigene is composed of the mouse Tyr enhancer region (623 bp), promoter region (657 bp), and 1566 bp cDNA sequence (including the stop codon); all in antisense orientation relative to the FUGW backbone. The Tyro minigene is followed by an internal ribosome entry site (IRES) ending with ATGs in all three reading frames (3xATG), an artificial splice donor sequence, and a loxP site in this construct. In line 2356A-2b1, the lentiviral transgene inserted into 3' UTR (NCBI37/mm9; 3'-24,829,538(-)) in sense orientation relative to the disrupted gene. (J:175597)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mrpl41 Mutation:	8 strains or lines available

Original:	J:175597 Overbeek PA, Direct Data Submission for Overbeek Lentiviral Transgenic Lines. MGI Direct Data Submission. 2011;
All:	1 reference(s)