Tg(CMV-KRAS*G12V,-EGFP)#Mjar
Transgene Detail
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| Symbol: |
Tg(CMV-KRAS*G12V,-EGFP)#Mjar |
| Name: |
transgene insertion, MJ Arends |
| MGI ID: |
MGI:5286106 |
| Synonyms: |
K-rasV12 |
| Transgene: |
Tg(CMV-KRAS*G12V,-EGFP)#Mjar Location: unknown
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| Alliance: |
Tg(CMV-KRAS*G12V,-EGFP)#Mjar page
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| Transgene Type: |
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Transgenic (Humanized sequence, Inserted expressed sequence, Reporter) |
| Mutation: |
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Insertion
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Mutation details: A CMV promoter drives ubiquitous expression of a human KRAS minigene with a nucleotide substitution that results in the amino acid substitution of valine for glycine at position 12, an IRES, and EGFP. The minigene is preceded by a floxed neo cassette. Cre-mediated recombination is required to allow for expression of the Kras mutation that occurs in 40-50% of human colorectal adenomas and carcinomas.
(J:122904)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:122904 Luo F, et al., Conditional expression of mutated K-ras accelerates intestinal tumorigenesis in Msh2-deficient mice. Oncogene. 2007 Jun 28;26(30):4415-27 |
| All: |
4 reference(s) |
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Analysis Tools
