Tet2tm1.1Rao
Targeted Allele Detail
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| Symbol: |
Tet2tm1.1Rao |
| Name: |
tet methylcytosine dioxygenase 2; targeted mutation 1.1, Anjana Rao |
| MGI ID: |
MGI:5285412 |
| Gene: |
Tet2 Location: Chr3:133169438-133250882 bp, - strand Genetic Position: Chr3, 61.84 cM
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| Alliance: |
Tet2tm1.1Rao page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:175222
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| Parent Cell Line: |
ART B6-3, B6-3 (ES Cell)
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| Strain of Origin: |
C57BL/6NTac
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| Allele Type: |
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Targeted (Conditional ready, No functional change) |
| Mutation: |
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Insertion
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Mutation details: A loxP site was inserted upstream of exon 8 and an FRT flanked neo cassette and second loxP site were inserted downstream of exon 10 via homologous recombination. Flp mediated recombination removed the neo cassette.
(J:175222)
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Targeting strategy to generate the Tet2tm1.1Rao and Tet2tm1.2Rao alleles |
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Tet2 Mutation: |
778 strains or lines available
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| Original: |
J:175222 Ko M, et al., Ten-Eleven-Translocation 2 (TET2) negatively regulates homeostasis and differentiation of hematopoietic stem cells in mice. Proc Natl Acad Sci U S A. 2011 Aug 30;108(35):14566-71 |
| All: |
12 reference(s) |
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Analysis Tools
