Summary | Transgene origin | Transgene description | Find Mice (IMSR) | References

Symbol:	Tg(H2-Kb-NFKB2*)452Hfdg
Name:	transgene insertion 452, Han-Fei Ding
MGI ID:	MGI:5141614
Synonyms:	NF-kB2 p52_452
Transgene:	Tg(H2-Kb-NFKB2*)452Hfdg  Location: unknown
Alliance:	Tg(H2-Kb-NFKB2*)452Hfdg page

Strain of Origin:

(C57BL/6J x SJL/J)F2

Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence) Mutation:    Insertion   Tg(H2-Kb-NFKB2*)452Hfdg expresses 1 gene Transgene expresses: Organism Expressed Gene Homolog in Mouse Note human NFKB2 (4791) Nfkb2  (MGI:1099800)   Mutation details: A transgenic construct containing the coding sequence for human NFKB p52 using a H2-Kb promoter and an immunoglobulin mu chain enhancer. Lines 434 and 452 were generated. (J:136017)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:136017 Wang Z, et al., Constitutive production of NF-kappaB2 p52 is not tumorigenic but predisposes mice to inflammatory autoimmune disease by repressing Bim expression. J Biol Chem. 2008 Apr 18;283(16):10698-706
All:	2 reference(s)