Summary | Mutation origin | Mutation description | Recombinase activity | Phenotypes | Find Mice (IMSR) | References

Symbol:	Pax7tm1(cre/ERT2)Gaka
Name:	paired box 7; targeted mutation 1, Gabrielle Kardon
MGI ID:	MGI:5141477
Gene:	Pax7  Location: Chr4:139464373-139560839 bp, - strand  Genetic Position: Chr4, 70.83 cM
Alliance:	Pax7tm1(cre/ERT2)Gaka page

Germline Transmission:	Earliest citation of germline transmission: J:174914
Parent Cell Line:	G4 (ES Cell)
Strain of Origin:	(129S6/SvEvTac x C57BL/6NCrl)F1

Allele Type:    Targeted (Inducible, Recombinase) Inducer:    tamoxifen Mutation:    Insertion   Pax7tm1(cre/ERT2)Gaka expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Pax7 (MGI:97491)   Mutation details: An IRES-cre/ERT2 and an FRT flanked neomycin selection cassette were inserted 8 bp after the endogenous stop codon. The selection cassette was subsequently removed by crossing to a Gt(ROSA)26Sortm1(FLP1)Dym mouse line. Endogenous gene function is preserved. (J:174914)

Activity:	Tissue activity of this recombinase allele
Driver:	Pax7 (mouse) Summary of all recombinase alleles driven by Pax7. Comparative matrix view of recombinase activities Alliance mouse Pax7 gene page

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pax7 Mutation:	39 strains or lines available

Original:	J:174914 Murphy MM, et al., Satellite cells, connective tissue fibroblasts and their interactions are crucial for muscle regeneration. Development. 2011 Sep;138(17):3625-37
All:	79 reference(s)