Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Nlrp6tm1Macha Name: NLR family, pyrin domain containing 6; targeted mutation 1, Mathias Chamaillard MGI ID: MGI:5140329 Gene: Nlrp6  Location: Chr7:140500815-140509105 bp, + strand  Genetic Position: Chr7, 86.14 cM, cytoband F4 Alliance: Nlrp6tm1Macha page

Increased susceptibility to induced colitis in Nlrp6tm1Macha/Nlrp6tm1Macha mice Show the 2 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:173352
Parent Cell Line:	Lex-1 (ES Cell)
Strain of Origin:	129S5/SvEvBrd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The first two exons were replaced with a neo cassette. The absence of transcript expression was confirmed by RT-PCR. (J:173352)

Generation of the Nlrp6tm1Macha allele

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nlrp6 Mutation:	43 strains or lines available

Original:	J:173352 Normand S, et al., Nod-like receptor pyrin domain-containing protein 6 (NLRP6) controls epithelial self-renewal and colorectal carcinogenesis upon injury. Proc Natl Acad Sci U S A. 2011 Jun 7;108(23):9601-6
All:	1 reference(s)