Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol:	Trp53tm4Att
Name:	transformation related protein 53; targeted mutation 4, Laura D Attardi
MGI ID:	MGI:5140078
Synonyms:	p53LSL-25,26,53,54
Gene:	Trp53  Location: Chr11:69471185-69482699 bp, + strand  Genetic Position: Chr11, 42.83 cM, cytoband B2-C
Alliance:	Trp53tm4Att page

Germline Transmission:	Earliest citation of germline transmission: J:173395
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Conditional ready, Null/knockout) Mutations:    Insertion, Nucleotide substitutions   Mutation details: A loxP site flanked puromycin resistance gene/transcription stop cassette was inserted into intron 1 and mutations were created in exon 2 altering codon 25 from leucine to glutamine (p.L25Q) and codon 26 from tryptophan to serine (p.W26S). Further changes in exon 4 altered codon 53 from phenylalanine to glutamine (p.F53Q) and codon 54 from phenylalanine to serine (p.F54S). Both transactivation domains are incapacitated once the stop sequences are removed by cre expression. (J:173395)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

17 anatomical structure(s)

List all tumor models in MMHCdb carrying Trp53tm4Att

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Trp53 Mutation:	232 strains or lines available

Original:	J:173395 Brady CA, et al., Distinct p53 transcriptional programs dictate acute DNA-damage responses and tumor suppression. Cell. 2011 May 13;145(4):571-83
All:	6 reference(s)