About   Help   FAQ
Gene Expression Data
Assay Details
Assay
Reference: J:81589 Wada H, et al., In situ expression of heat shock proteins, Hsc73, Hsj2 and Hsp86 in the developing tooth germ of mouse lower first molar. Histochem J. 2002 Mar-Apr;34(3-4):105-9
Assay type: RNA in situ
MGI Accession ID: MGI:5056454
Gene symbol: Hspa8
Gene name: heat shock protein 8
Probe: Hsc73 cDNA
Probe preparation: Antisense labelled with digoxigenin RNA
Visualized with: Alkaline phosphatase
Results
Specimen 1A: embryonic day 11.0 (more )
Note: Initiation stage of tooth development.
Structure Level Pattern Image Note
TS18: 1st branchial arch mandibular component mesenchyme Present Regionally restricted 1A Expression is diffuse in the mesenchymal cells corresponding to the area where the first molar would be formed.
TS18: oral epithelium Weak Regionally restricted 1A Expression is in oral mucosal cells.
Specimen 1D: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: mandibular process mesenchyme Present Regionally restricted 1D Expressing cells are at the area where the tooth germ will be formed, stronger on the buccal side than the lingual side.
Specimen 1G: embryonic day 13.0 (more )
Structure Level Pattern Image Note
TS21: lower jaw molar mesenchyme Present 1G
TS21: tooth bud Present 1G
Specimen 1J: embryonic day 14.0 (more )
Structure Level Pattern Image Note
TS22: lower jaw molar mesenchyme Weak 1J
TS22: lower jaw molar enamel organ Present Regionally restricted 1J Expression is in odontogenic epithelial cells.
TS22: oral epithelium Present Regionally restricted 1J Expression is in oral mucosal cells.
Specimen 2A: embryonic day 15.0 (more )
Structure Level Pattern Image Note
TS23: lower jaw molar enamel organ Strong Regionally restricted 2A Expression is in the lateral odontogenic epithelial cells and is weak in the central area of the enamel organ, the primary enamel knot.
TS23: primary enamel knot Strong Regionally restricted 2A Expression is in the lateral odontogenic epithelial cells and is weak in the central area of the enamel organ, the primary enamel knot.
TS23: dental sac Weak 2A
TS23: lower jaw molar dental papilla Weak 2A
TS23: cap stage tooth Present Regionally restricted 2A
Specimen 2D: embryonic day 16.0 (more )
Structure Level Pattern Image Note
TS24: lower jaw molar dental papilla Strong 2D
TS24: lower jaw molar enamel organ Strong 2D
Specimen 2G: embryonic day 17.0 (more )
Structure Level Pattern Image Note
TS25: inner enamel epithelium Present 2G
TS25: lower jaw molar dental papilla Present Regionally restricted 2G Expression is in cells facing the inner epithelial layer.
TS25: bell stage tooth Present Regionally restricted 2G
Specimen 2J: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: inner enamel epithelium Present 2J
TS26: lower jaw molar dental papilla Present Regionally restricted 2J Expression is in cells facing the inner epithelial layer (odontoblasts).
TS26: bell stage tooth Present Regionally restricted 2J
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory