Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Casp3hith2
Name:	caspase 3; hole in the head 2
MGI ID:	MGI:5056374
Gene:	Casp3  Location: Chr8:47070326-47092724 bp, + strand  Genetic Position: Chr8, 26.39 cM
Alliance:	Casp3hith2 page

Strain of Origin:

A/J

Allele Type:    Chemically induced (ENU) Mutation:    Nucleotide substitutions   Mutation details: Identified in an ENU screen and mapped to a 4 Mb interval on Chromosome 8 containing Casp3. A mutation two bases upstream of exon 3 results in splicing errors causing exon 3 splicing to be 4 nucleotides into the wild type exon or loss of exon 3 altogether. Both forms result in premature stop codons. (J:174027)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Casp3 Mutation:	31 strains or lines available

Original:	J:174027 Stottmann RW, et al., Focusing Forward Genetics: A Tripartite ENU Screen for Neurodevelopmental Mutations in the Mouse. Genetics. 2011 Jul;188(3):615-24
All:	1 reference(s)