Summary | Transgene origin | Transgene description | Recombinase activity | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tg(Pdgfra-cre/ERT)467Dbe
Name:	transgene insertion 467, Dwight E Bergles
MGI ID:	MGI:5056164
Synonyms:	PDGRaR-CreER
Transgene:	Tg(Pdgfra-cre/ERT)467Dbe  Location: unknown
Alliance:	Tg(Pdgfra-cre/ERT)467Dbe page

Strain of Origin:

C57BL/6 x SJL

Transgene Type:    Transgenic (Inducible, Recombinase) Inducer:    tamoxifen Mutation:    Insertion   Tg(Pdgfra-cre/ERT)467Dbe expression driven by 1 gene Transgene expression driven by: Organism Driver Gene Note mouse Pdgfra (MGI:97530)   Mutation details: A BAC clone (RP24-148N) was modified by homologous recombination to generate an inducible cre transgene. The cDNA encoding tamoxifen-inducible cre recombinase (cre/ERT) was inserted after the 5' UTR, followed by a rabbit beta-globin poly adenylation sequence. The linearized 150kb construct was injected into pronuclei of 1- or 2-cell stage nuclei from B6SJL mice. Four founders were obtained and crossed to Z/EG reporter animals to assay EGFP expression in offspring. Line 467 displayed the highest cre efficiency and was chosen for further studies. (J:167748)

Activity:	Tissue activity of this recombinase allele
Driver:	Pdgfra (mouse) Summary of all recombinase alleles driven by Pdgfra. Comparative matrix view of recombinase activities Alliance mouse Pdgfra gene page

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:167748 Kang SH, et al., NG2+ CNS glial progenitors remain committed to the oligodendrocyte lineage in postnatal life and following neurodegeneration. Neuron. 2010 Nov 18;68(4):668-81
All:	114 reference(s)