Summary | Mutation origin | Mutation description | Expression | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Dbx1tm1.1(cre)Mull
Name:	developing brain homeobox 1; targeted mutation 1.1, Ulrich Mueller
MGI ID:	MGI:5014205
Synonyms:	Dbx1-IRES-Cre
Gene:	Dbx1  Location: Chr7:49281247-49286583 bp, - strand  Genetic Position: Chr7, 31.44 cM
Alliance:	Dbx1tm1.1(cre)Mull page

Germline Transmission:	Earliest citation of germline transmission: J:151755
Parent Cell Line:	Bruce 4 (ES Cell)
Strain of Origin:	B6.Cg-Thy1a
Project Collection:	Neuroscience Blueprint cre

Allele Type:    Targeted (Recombinase) Mutation:    Insertion   Dbx1tm1.1(cre)Mull expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Dbx1 (MGI:94867)   Mutation details: A targeting vector was designed to insert an internal ribosomal entry site, nuclear-localized Cre recombinase gene (NLS-Cre), and polyA signal (IRES-Cre-pA), all followed by an FRT-flanked PGK-Neo cassette into the 3' untranslated region of the developing brain homeobox 1 (Dbx1) locus. This construct was electroporated into C57BL/6-derived Bruce4 embryonic stem (ES) cells. Chimeric mice were bred to albino B6(Cg)-Tyrc-2J/J mice. Next, mutant mice were bred with FLPe-expressing mice on a C57BL/6 congenic background to remove the FRT-flanked PGK-Neo cassette. The resulting Dbx1-IRES-Cre mutant mice were then bred to C57BL/6J inbred mice for many generations (selecting away from the FLPe transgene). (J:151755)

Activity:	Tissue activity of this recombinase allele
Driver:	Dbx1 (mouse) Summary of all recombinase alleles driven by Dbx1. Comparative matrix view of recombinase activities Alliance mouse Dbx1 gene page

In Mice Carrying this Mutation:

10 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Dbx1 Mutation:	25 strains or lines available

Original:	J:151755 NIH Neuroscience Blueprint Cre Driver Network, Cre recombinase-expressing mice generated for the NIH Neuroscience Blueprint Cre Driver Network. MGI Direct Data Submission. 2009;
All:	7 reference(s)