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Tg(Igh-6H4Vh/Ighm*a)508Zbz
Transgene Detail
Summary
Symbol: Tg(Igh-6H4Vh/Ighm*a)508Zbz
Name: transgene insertion 508, Universitatsspital Zurich, Biologisches Zentrallaboratorium
MGI ID: MGI:5014082
Synonyms: 6H4mu, Tg(6H4u)508, TgN(6H4IgH)508
Transgene: Tg(Igh-6H4Vh/Ighm*a)508Zbz  Location: unknown  
Alliance: Tg(Igh-6H4Vh/Ighm*a)508Zbz page
Transgene
origin
Strain of Origin:  B6;129S7-Prnptm1Cwe
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Igh-6H4Vh/Ighm*a)508Zbz expresses 2 genes
 
Mutation details: This transgene encodes an immunoglobulin heavy chain (IgH) whose variable region is that of the monoclonal antibody expressed by the hybridoma cell line 6H4, which recognizes the normal endogenous mouse prion protein (PRNP); this is joined to the IgH-mu constant region (Cu) of the IgHa haplotype. Transgenic mice develop high titres of anti-PRNP antibodies composed of transgene-derived IgMa mu heavy chains paired with various endogenously encoded immunoglobulin kappa and lambda light chains, but have no detectable IgHM/D from endogenous genes. (J:127850)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Notes
Six mice that had integrated this transgenic construct were designated 508-511, 513 and 514. Four of these mice (unspecified) expressed the transgene. Mice descended from founder 508 - the present line - were employed in all experiments described. (J:127850)
References
Original:  J:127850 Heppner FL, et al., Prevention of scrapie pathogenesis by transgenic expression of anti-prion protein antibodies. Science. 2001 Oct 5;294(5540):178-82
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/28/2024
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