Summary | Transgene origin | Transgene description | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Tg(SFTPC-rtTA)2Jaw
Name:	transgene insertion 2, Jeffrey A Whitsett
MGI ID:	MGI:5000438
Synonyms:	SP-C-rtTA (line 2)
Transgene:	Tg(SFTPC-rtTA)2Jaw  Location: unknown
Alliance:	Tg(SFTPC-rtTA)2Jaw page

Strain of Origin:

129 and C57BL/6

Transgene Type:    Transgenic (Transactivator) Mutation:    Insertion   Mutation details: The transgene is composed of 3.7 kb of human SFTPC promoter, a reverse tetracycline responsive transactivator gene (rt-TA), and a 0.45 kb SV40 polyadenylation signal. Transgene expression was confirmed by RT-PCR analysis. The human SFTPC promoter is active in respiratory epithelial cells. (J:61736)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:171151 Chen S, et al., CTGF disrupts alveolarization and induces pulmonary hypertension in neonatal mice: implication in the pathogenesis of severe bronchopulmonary dysplasia. Am J Physiol Lung Cell Mol Physiol. 2011 Mar;300(3):L330-40
All:	6 reference(s)