Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Gabra2tm1.1Geh
Name:	gamma-aminobutyric acid type A receptor subunit alpha 2; targeted mutation 1.1, Gregg E Homanics
MGI ID:	MGI:5000434
Synonyms:	Gabra2HA
Gene:	Gabra2  Location: Chr5:71115735-71253192 bp, - strand  Genetic Position: Chr5, 37.59 cM
Alliance:	Gabra2tm1.1Geh page

Germline Transmission:	Earliest citation of germline transmission: J:171967
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Nucleotide substitutions   Mutation details: The targeting vector was designed (by site-directed mutagenesis) to substitute a serine to histidine at amino acid position 270 and leucine to alanine at amino acid position 277 of exon 9. An FRT-flanked PGKneo cassette was inserted downstream of exon 9. Flp-mediated recombination removed the neo cassette and left a single FRT site downstream of exon 9. (J:171967)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gabra2 Mutation:	34 strains or lines available

Original:	J:171967 Werner DF, et al., Inhaled anesthetic responses of recombinant receptors and knockin mice harboring alpha2(S270H/L277A) GABA(A) receptor subunits that are resistant to isoflurane. J Pharmacol Exp Ther. 2011 Jan;336(1):134-44
All:	2 reference(s)