Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Boctm2Rsk
Name:	BOC cell adhesion associated, oncogene regulated; targeted mutation 2, Robert S Krauss
MGI ID:	MGI:5000229
Synonyms:	Boc-, BocAP-2
Gene:	Boc  Location: Chr16:44305408-44379233 bp, - strand  Genetic Position: Chr16, 28.81 cM, cytoband B5
Alliance:	Boctm2Rsk page

Germline Transmission:	Earliest citation of germline transmission: J:171767
Parent Cell Line:	TC1/TC-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout, Reporter) Mutation:    Insertion   Mutation details: An IRES-hAP and floxed PGK-neo cassette was inserted in exon 2 via homologous recombination. Western blot analysis confirmed the absence of protein expression in homozygous embryos. Alkaline phosphatase activity mirrors endogenous gene expression. (J:171767)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

76 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Boc Mutation:	61 strains or lines available

Original:	J:171767 Zhang W, et al., Boc modifies the holoprosencephaly spectrum of Cdo mutant mice. Dis Model Mech. 2011 May-Jun;4(3):368-80
All:	7 reference(s)