Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Dazap1tm1Pyen
Name:	DAZ associated protein 1; targeted mutation 1, Pauline Yen
MGI ID:	MGI:4950677
Synonyms:	Dazap1fn, Dazaptm115FnYen
Gene:	Dazap1  Location: Chr10:80097320-80124242 bp, + strand  Genetic Position: Chr10, 39.72 cM
Alliance:	Dazap1tm1Pyen page

Germline Transmission:	Earliest citation of germline transmission: J:171493
Parent Cell Line:	TC1/TC-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Conditional ready) Mutation:    Insertion   Mutation details: One loxP site was inserted just upstrean of exon 2 and a floxed neomycin selection cassette in reverse orientation was inserted in intron 4. Exons 2-4 which encode the first RNA binding domain were thus flanked by loxP sites. This allele expresses an aberrant transcript 500 bp longer than expected because of an additional exon encoding an additional 166 amino acids. Low amounts of a 64 kDalton protein are produced. (J:171493)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	8 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dazap1 Mutation:	39 strains or lines available

Original:	J:171493 Hsu LC, et al., DAZAP1, an hnRNP protein, is required for normal growth and spermatogenesis in mice. RNA. 2008 Sep;14(9):1814-22
All:	2 reference(s)