Summary | Mutation origin | Mutation description | Recombinase activity | Phenotypes | Find Mice (IMSR) | References

Symbol:	Cspg4tm1(cre)Akik
Name:	chondroitin sulfate proteoglycan 4; targeted mutation 1, Akiko Nishiyama
MGI ID:	MGI:4950067
Synonyms:	NG2CreKI, NG2 KO
Gene:	Cspg4  Location: Chr9:56772388-56807154 bp, + strand  Genetic Position: Chr9, 30.32 cM
Alliance:	Cspg4tm1(cre)Akik page

Germline Transmission:	Earliest citation of germline transmission: J:171287
Parent Cell Line:	RENKA (ES Cell)
Strain of Origin:	C57BL/6N

Allele Type:    Targeted (Null/knockout, Recombinase) Mutations:    Insertion, Intragenic deletion   Cspg4tm1(cre)Akik expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Cspg4 (MGI:2153093)   Mutation details: A targeting vector was designed so that it contained a homology arm-flanked nlsCre cDNA (nls;nuclear localization signal), a pgk-neo cassette 3' of the nlscre, and an MC1-driven diphtheria toxin selection gene. After homologous recombination in RENKA ES cells, targeted clones had the cre cDNA inserted immediately after the translational initiation codon of Cspg4. ES cell clones were injected into 8-cell CD1 embryos to produce germline chimeras to establish the knock-in line. (J:171287)

Activity:	Tissue activity of this recombinase allele
Driver:	Cspg4 (mouse) Summary of all recombinase alleles driven by Cspg4. Alliance mouse Cspg4 gene page

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cspg4 Mutation:	102 strains or lines available

Original:	J:171287 Hill RA, et al., NG2 cells are uniformly distributed and NG2 is not required for barrel formation in the somatosensory cortex. Mol Cell Neurosci. 2011 Apr;46(4):689-98
All:	2 reference(s)