Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Slc25a25tm1.1Kz
Name:	solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 25; targeted mutation 1.1, Leslie P Kozak
MGI ID:	MGI:4948968
Gene:	Slc25a25  Location: Chr2:32304499-32341457 bp, - strand  Genetic Position: Chr2, 22.09 cM
Alliance:	Slc25a25tm1.1Kz page

Germline Transmission:	Earliest citation of germline transmission: J:170924
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	C57BL/6J

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A loxP site was inserted upstream of exon 2. A floxed neo cassette was inserted downstream of exon 3. Cre-mediated recombination removed the neo cassette. The absence of transcript expression was confirmed by qRT-PCR analysis of liver, quadriceps, and inguinal fat extracts. (J:170924)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Slc25a25 Mutation:	40 strains or lines available

Original:	J:170924 Anunciado-Koza RP, et al., Inactivation of the Mitochondrial Carrier SLC25A25 (ATP-Mg2+/Pi Transporter) Reduces Physical Endurance and Metabolic Efficiency in Mice. J Biol Chem. 2011 Apr 1;286(13):11659-71
All:	1 reference(s)