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Tg(SYN1-icre/mRFP1)9934Rdav
Transgene Detail
Summary
Symbol: Tg(SYN1-icre/mRFP1)9934Rdav
Name: transgene insertion 9934, Ron Davis
MGI ID: MGI:4947576
Transgene: Tg(SYN1-icre/mRFP1)9934Rdav  Location: unknown  
Alliance: Tg(SYN1-icre/mRFP1)9934Rdav page
Transgene
origin
Strain of Origin:  C57BL/6J
Transgene
description
Transgene Type:    Transgenic (Recombinase)
Mutation:    Insertion
 
Tg(SYN1-icre/mRFP1)9934Rdav expression driven by 1 gene
 
Mutation detailsA lentiviral transgenic approach was used to generate these mice. The synapsin-iCre-RFP lentiviral transgene was designed with a 450 bp human synapsin I promoter, codon-improved cre/monomeric red fluorescent protein fusion protein (icre/mRFP1), and woodchuck hepatitis virus post-transcriptional regulatory element (WPRE; to enhance the mRNA transcript stability). This packaged lentivirus was injected subzonally (under the zona pellucida) into 1-2 cell stage C57BL/6J mouse embryos. Founders were crossed to C57BL/6 animals. Animals were crossed to B6-Gt(ROSA)26Sortm1Sor mice to assess cre activity/transmission. Cre positive, lacZ negative mice were subsequently bred to C57BL/6 mice to create the 9934 line. (J:150856)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: SYN1 (human)
Summary of all recombinase alleles driven by SYN1.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:150856 Davis R, Large-scale enhancer trap project to generate transgenic cre alleles by Ron Davis at Baylor University. MGI Direct Data Submission. 2009;
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory