Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Selenontm1.2Mred
Name:	selenoprotein N; targeted mutation 1.2, Mathieu Rederstorff
MGI ID:	MGI:4946396
Gene:	Selenon  Location: Chr4:134265203-134279477 bp, - strand  Genetic Position: Chr4, 66.85 cM, cytoband D3
Alliance:	Selenontm1.2Mred page

Germline Transmission:	Earliest citation of germline transmission: J:168699
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A loxP site was inserted upstream of exon 3. A floxed neo cassette was inserted downstream of exon 3. Cre-mediated recombination removed exon 3 and the neo cassette. Western blot analysis on skeletal muscle. heart, lung, liver, brain, and kidney extracts confirmed the absence of protein expression. (J:176499)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	19 assay results
In Structures Affected by this Mutation:	8 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Selenon Mutation:	26 strains or lines available

Original:	J:168699 Castets P, et al., Satellite cell loss and impaired muscle regeneration in selenoprotein N deficiency. Hum Mol Genet. 2011 Feb 15;20(4):694-704
All:	7 reference(s)