Summary | Mutation origin | Mutation description | Expression | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Gja5tm2(cre/ERT2,RFP)Lumi
Name:	gap junction protein, alpha 5; targeted mutation 2, Lucile Miquerol
MGI ID:	MGI:4941829
Synonyms:	Cx40-CreERT2
Gene:	Gja5  Location: Chr3:96939718-96960950 bp, + strand  Genetic Position: Chr3, 42.04 cM
Alliance:	Gja5tm2(cre/ERT2,RFP)Lumi page

Germline Transmission:	Earliest citation of germline transmission: J:169695
Parent Cell Line:	CK35 (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Inducible, Recombinase) Inducer:    tamoxifen Mutations:    Insertion, Intragenic deletion   Gja5tm2(cre/ERT2,RFP)Lumi expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Gja5 (MGI:95716)   Mutation details: A cre/ERT2 cassette followed by an IRES::mRFP1 (monomeric RFP) sequence along with a PGK-neo cassette was introduced at the ATG site in exon 2 of the Gja5 locus, replacing the exon 2 sequence. (J:169695)

Generation of the Gja5tm2(cre/ERT2,RFP)Lumi allele

Activity:	Tissue activity of this recombinase allele
Driver:	Gja5 (mouse) Summary of all recombinase alleles driven by Gja5. Comparative matrix view of recombinase activities Alliance mouse Gja5 gene page

In Mice Carrying this Mutation:

1 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gja5 Mutation:	18 strains or lines available

Original:	J:169695 Beyer S, et al., Inducible Cx40-Cre expression in the cardiac conduction system and arterial endothelial cells. Genesis. 2011 Feb;49(2):83-91
All:	7 reference(s)