Summary | Transgene origin | Transgene description | Recombinase activity | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tg(Aqp2-cre/ERT2)4Gsc
Name:	transgene insertion 4, Gunther Schutz
MGI ID:	MGI:4941815
Synonyms:	AQP2CreERT2
Transgene:	Tg(Aqp2-cre/ERT2)4Gsc  Location: unknown
Alliance:	Tg(Aqp2-cre/ERT2)4Gsc page

Strain of Origin:

FVB/N

Transgene Type:    Transgenic (Inducible, Recombinase) Inducer:    tamoxifen Mutation:    Insertion   Tg(Aqp2-cre/ERT2)4Gsc expression driven by 1 gene Transgene expression driven by: Organism Driver Gene Note mouse Aqp2 (MGI:1096865)   Mutation details: A genomic fragment of the murine Aqp2 gene in a PAC was modified by homologous recombination in bacterias to put the sequence for a cre/ERT2 fusion protein at the ATG site of the Aqp2 locus. This construct was microinjected into FVB/N pronuclei to produce transgenic animals. 3 lines with 1, 4, and 9 copies of the transgene were established and analyzed for cre expression. The lines show copy number-dependent quantitative differences but have identical expression profiles. The line with 4 copies was chosen for further studies. (J:169670)

Activity:	Tissue activity of this recombinase allele
Driver:	Aqp2 (mouse) Summary of all recombinase alleles driven by Aqp2. Alliance mouse Aqp2 gene page

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available

Original:	J:169670 Ronzaud C, et al., Inducible renal principal cell-specific mineralocorticoid receptor gene inactivation in mice. Am J Physiol Renal Physiol. 2011 Mar;300(3):F756-60
All:	1 reference(s)